Melt margarine or butter in a small saucepan. Remove saucepan from heat and stir in honey mustard, Worcestershire sauce, garlic powder, and hot pepper sauce. Place pretzels in a foil-lined 15 x 10 x 1-inch baking pan. Pour mustard mixture over pretzels; toss gently to coat. Bake in a 300 degree oven for 25 minutes, stirring every 10 minutes. Spread on foil; cool. Store in an airtight container.